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In situ structure of capping enzyme lambda2, penetration protein mu1 of mammalian reovirus capsid asymmetric unit.

Source organism: Mammalian orthoreovirus 3
Biochemical function: host cell surface binding
Biological process: symbiont entry into host cell
Cellular component: viral outer capsid

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EC 2.7.7.50: mRNA guanylyltransferase

Reaction catalysed:
GTP + a 5'-diphospho-[mRNA] = diphosphate + a 5'-(5'-triphosphoguanosine)-[mRNA]
Systematic name:
GTP:mRNA guanylyltransferase
Alternative Name(s):
  • GTP--RNA guanylyltransferase
  • Messenger RNA guanylyltransferase
  • Protein lambda-2
  • mRNA capping enzyme

EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF05993
Domain description: Reovirus major virion structural protein Mu-1/Mu-1C (M2)
Occurring in:
  1. Outer capsid protein mu-1
The deposited structure of PDB entry 7ell contains 10 copies of Pfam domain PF05993 (Reovirus major virion structural protein Mu-1/Mu-1C (M2)) in Outer capsid protein mu-1. Showing 1 copy in chain T [auth j].

PF06016
Domain description: Reovirus core-spike protein lambda-2 (L2), C-terminal
Occurring in:
  1. Outer capsid protein lambda-2
The deposited structure of PDB entry 7ell contains 1 copy of Pfam domain PF06016 (Reovirus core-spike protein lambda-2 (L2)) in Outer capsid protein lambda-2. Showing 1 copy in chain U [auth K].

PF21061
Domain description: Reovirus core-spike protein lambda-2 (L2), 7th domain
Occurring in:
  1. Outer capsid protein lambda-2

PF21060
Domain description: Reovirus core-spike protein lambda-2 (L2), 6th domain
Occurring in:
  1. Outer capsid protein lambda-2

PF21066
Domain description: Reovirus core-spike protein lambda-2 (L2), methyltransferase-2
Occurring in:
  1. Outer capsid protein lambda-2

PF21062
Domain description: Reovirus core-spike protein lambda-2 (L2), ferredoxin-like domain
Occurring in:
  1. Outer capsid protein lambda-2

PF21065
Domain description: Reovirus core-spike protein lambda-2 (L2), methyltransferase-1
Occurring in:
  1. Outer capsid protein lambda-2

PF21063
Domain description: Reovirus core-spike protein lambda-2 (L2), GTase domain
Occurring in:
  1. Outer capsid protein lambda-2

PF21064
Domain description: Reovirus core-spike protein lambda-2 (L2), N-terminal
Occurring in:
  1. Outer capsid protein lambda-2

InterPro InterPro annotations
IPR036256
Domain description: Mu1/VP4 superfamily
Occurring in:
  1. Outer capsid protein mu-1N
  2. Outer capsid protein mu-1
IPR009113
Domain description: Outer capsid protein Mu1/VP4
Occurring in:
  1. Outer capsid protein mu-1N
  2. Outer capsid protein mu-1
IPR015960
Domain description: Mu1 membrane penetration protein, domain IV
Occurring in:
  1. Outer capsid protein mu-1
IPR044937
Domain description: Mu1 membrane penetration protein, domain III
Occurring in:
  1. Outer capsid protein mu-1
IPR015962
Domain description: Mu1 membrane penetration protein, domain II
Occurring in:
  1. Outer capsid protein mu-1
IPR015961
Domain description: Mu1 membrane penetration protein, domain I
Occurring in:
  1. Outer capsid protein mu-1
IPR010311
Domain description: Reovirus core-spike lambda-2
Occurring in:
  1. Outer capsid protein lambda-2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Outer capsid protein lambda-2
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Outer capsid protein lambda-2

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