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Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate

Source organism: Homo sapiens
Biochemical function: ligand-gated monoatomic ion channel activity
Biological process: monoatomic ion transport
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00060
Domain description: Ligand-gated ion channel
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF00060 (Ligand-gated ion channel) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF00060 (Ligand-gated ion channel) in Glutamate receptor ionotropic, NMDA 2A. Showing 1 copy in chain B.

PF10613
Domain description: Ligated ion channel L-glutamate- and glycine-binding site
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF10613 (Ligated ion channel L-glutamate- and glycine-binding site) in Glutamate receptor ionotropic, NMDA 2A. Showing 1 copy in chain B.

PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 7eu7 contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 2A. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001508
Domain description: Ionotropic glutamate receptor, metazoa
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 2A
IPR019594
Domain description: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
IPR001320
Domain description: Ionotropic glutamate receptor, C-terminal
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
IPR001828
Domain description: Receptor, ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
IPR015683
Domain description: Ionotropic glutamate receptor
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2A
IPR028082
Domain description: Periplasmic binding protein-like I
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 2A

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