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Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate

Electron Microscopy
3.5Å resolution
PDB entry 7eu7 coloured by chain, front view.
PDB entry 7eu7 coloured by chain, side view.
PDB entry 7eu7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NMDA receptor complex, GluN1-GluN2A
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Multimeric state: hetero tetramer
Accessible surface area: 137154.39 Å2
Buried surface area: 22663.43 Å2
Dissociation area: 4,132.46 Å2
Dissociation energy (ΔGdiss): 64.81 kcal/mol
Dissociation entropy (TΔSdiss): 17.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170224
Complex Portal ID: CPX-2202

Macromolecules

Glutamate receptor ionotropic, NMDA 1
Chains: A, C
Length: 847 amino acids
Theoretical weight: 95.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Pfam:
InterPro:
Glutamate receptor ionotropic, NMDA 1 in PDB entry 7eu7, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 7eu7, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 7eu7, assembly 1, top view.
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Glutamate receptor ionotropic, NMDA 2A
Chains: B, D
Length: 841 amino acids
Theoretical weight: 94.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12879 (Residues: 1-841; Coverage: 57%)
Gene names: GRIN2A, NMDAR2A
Pfam:
InterPro:
Glutamate receptor ionotropic, NMDA 2A in PDB entry 7eu7, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 2A in PDB entry 7eu7, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 2A in PDB entry 7eu7, assembly 1, top view.
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