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Crystal structure of PDE4D catalytic domain complexed with compound 18d

X-ray diffraction
2.2Å resolution
PDB entry 7f2m coloured by chain, front view.
PDB entry 7f2m coloured by chain, side view.
PDB entry 7f2m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3',5'-cyclic-AMP phosphodiesterase 4D
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Multimeric state: monomeric
Accessible surface area: 14509.39 Å2
Buried surface area: 232.43 Å2
Dissociation area: 73.84 Å2
Dissociation energy (ΔGdiss): 18.16 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170654
Assembly 2
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Assembly Name: 3',5'-cyclic-AMP phosphodiesterase 4D
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Multimeric state: monomeric
Accessible surface area: 14578.86 Å2
Buried surface area: 233.04 Å2
Dissociation area: 74.63 Å2
Dissociation energy (ΔGdiss): 18.52 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170654

Macromolecules

3',5'-cyclic-AMP phosphodiesterase 4D
Chains: A, B
Length: 507 amino acids
Theoretical weight: 57.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q08499 (Residues: 303-809; Coverage: 63%)
Gene names: DPDE3, PDE4D
Pfam:
InterPro:
3',5'-cyclic-AMP phosphodiesterase 4D in PDB entry 7f2m, assembly 1, front view.
3',5'-cyclic-AMP phosphodiesterase 4D in PDB entry 7f2m, assembly 1, side view.
3',5'-cyclic-AMP phosphodiesterase 4D in PDB entry 7f2m, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q08499  
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