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Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex

Source organisms:
Biochemical function: protein binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 7f55 contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain B.

PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. Melanocortin receptor 4
The deposited structure of PDB entry 7f55 contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in Melanocortin receptor 4. Showing 1 copy in chain E [auth R].

PF00631
Domain description: GGL domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 7f55 contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain C [auth G].

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 7f55 contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. Melanocortin receptor 4
IPR001671
Domain description: Melanocortin/ACTH receptor
Occurring in:
  1. Melanocortin receptor 4
IPR001908
Domain description: Melanocortin receptor 3-5
Occurring in:
  1. Melanocortin receptor 4
IPR000367
Domain description: G-protein alpha subunit, group S
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR000155
Domain description: Melanocortin 4 receptor
Occurring in:
  1. Melanocortin receptor 4
IPR015898
Domain description: G-protein gamma-like domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001770
Domain description: G-protein, gamma subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001632
Domain description: G-protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR012674
Domain description: Calycin
Occurring in:
  1. Melanocortin receptor 4
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Nanobody35
IPR036284
Domain description: G-protein gamma-like domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR011025
Domain description: G protein alpha subunit, helical insertion
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. Melanocortin receptor 4
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Nanobody35
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Nanobody35
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nanobody35
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Nanobody35
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR016346
Domain description: Guanine nucleotide-binding protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

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