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eIF2B-SFSV NSs

Electron Microscopy
2.42Å resolution
PDB entry 7f64 coloured by chain, front view.
PDB entry 7f64 coloured by chain, side view.
PDB entry 7f64 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eukaryotic translation initiation factor 2B complex and Non-structural protein NS-S
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Multimeric state: hetero dodecamer
Accessible surface area: 139964.95 Å2
Buried surface area: 38163.3 Å2
Dissociation area: 2,311.39 Å2
Dissociation energy (ΔGdiss): -1.77 kcal/mol
Dissociation entropy (TΔSdiss): 27.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146318

Macromolecules

Translation initiation factor eIF2B subunit alpha
Chains: A, B
Length: 305 amino acids
Theoretical weight: 33.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14232 (Residues: 1-305; Coverage: 100%)
Gene names: EIF2B1, EIF2BA
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit alpha in PDB entry 7f64, assembly 1, front view.
Translation initiation factor eIF2B subunit alpha in PDB entry 7f64, assembly 1, side view.
Translation initiation factor eIF2B subunit alpha in PDB entry 7f64, assembly 1, top view.
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Translation initiation factor eIF2B subunit beta
Chains: C, D
Length: 351 amino acids
Theoretical weight: 39.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49770 (Residues: 1-351; Coverage: 100%)
Gene names: EIF2B2, EIF2BB
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit beta in PDB entry 7f64, assembly 1, front view.
Translation initiation factor eIF2B subunit beta in PDB entry 7f64, assembly 1, side view.
Translation initiation factor eIF2B subunit beta in PDB entry 7f64, assembly 1, top view.
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Translation initiation factor eIF2B subunit gamma
Chains: E, F
Length: 452 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NR50 (Residues: 1-452; Coverage: 100%)
Gene name: EIF2B3
Pfam: Nucleotidyl transferase
InterPro:
Translation initiation factor eIF2B subunit gamma in PDB entry 7f64, assembly 1, front view.
Translation initiation factor eIF2B subunit gamma in PDB entry 7f64, assembly 1, side view.
Translation initiation factor eIF2B subunit gamma in PDB entry 7f64, assembly 1, top view.
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Translation initiation factor eIF2B subunit delta
Chains: G, H
Length: 523 amino acids
Theoretical weight: 57.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UI10 (Residues: 1-523; Coverage: 100%)
Gene names: EIF2B4, EIF2BD
Pfam: Initiation factor 2 subunit family
InterPro:
Translation initiation factor eIF2B subunit delta in PDB entry 7f64, assembly 1, front view.
Translation initiation factor eIF2B subunit delta in PDB entry 7f64, assembly 1, side view.
Translation initiation factor eIF2B subunit delta in PDB entry 7f64, assembly 1, top view.
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Translation initiation factor eIF2B subunit epsilon
Chains: I, J
Length: 721 amino acids
Theoretical weight: 80.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13144 (Residues: 1-721; Coverage: 100%)
Gene names: EIF2B5, EIF2BE
Pfam: eIF4-gamma/eIF5/eIF2-epsilon
InterPro:
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f64, assembly 1, front view.
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f64, assembly 1, side view.
Translation initiation factor eIF2B subunit epsilon in PDB entry 7f64, assembly 1, top view.
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Non-structural protein NS-S
Chains: K, L
Length: 261 amino acids
Theoretical weight: 29.7 KDa
Source organism: sandfly fever Sicilian virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P12792 (Residues: 7-267; Coverage: 98%)
Gene name: NSS
Pfam: Rift valley fever virus non structural protein (NSs) like
InterPro:
Non-structural protein NS-S in PDB entry 7f64, assembly 1, front view.
Non-structural protein NS-S in PDB entry 7f64, assembly 1, side view.
Non-structural protein NS-S in PDB entry 7f64, assembly 1, top view.
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