› 7f6v

Electron Microscopy
3.66Å resolution

Cryo-EM structure of the human TACAN channel in a closed state

Released:
DOI: 10.2210/pdb7f6v/pdb
PDB entry 7f6v coloured by chain, front view.
PDB entry 7f6v coloured by chain, side view.
PDB entry 7f6v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human TACAN in a closed state.
Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y
Cell Rep 38 110445 (2022)
PMID: 35235791
Related structures: EMD-31482

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion channel TACAN Chains: A, B
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 40.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BXJ8 (Residues: 1-343; Coverage: 100%)
Gene names: TACAN, TMEM120A, TMPIT
Sequence domains: TMPIT-like protein

Ligands and Environments

1 bound ligand:
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.66Å
Relevant EMDB volumes: EMD-31482
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels.
Chuang et al. (2022)
2 more

1 mention without citation

Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles.
Kang et al. (2024)