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Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

X-ray diffraction
3.491Å resolution
PDB entry 7f8g coloured by chain, front view.
PDB entry 7f8g coloured by chain, side view.
PDB entry 7f8g coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Eyes absent homolog 2
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Multimeric state: monomeric
Accessible surface area: 12225.11 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126128
Assembly 2
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Assembly Name: Eyes absent homolog 2
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Multimeric state: monomeric
Accessible surface area: 11825.75 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126128

Macromolecules

Eyes absent homolog 2
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00167 (Residues: 253-538; Coverage: 53%)
Gene names: EAB1, EYA2
Pfam: haloacid dehalogenase-like hydrolase
InterPro:
Eyes absent homolog 2 in PDB entry 7f8g, assembly 1, front view.
Eyes absent homolog 2 in PDB entry 7f8g, assembly 1, side view.
Eyes absent homolog 2 in PDB entry 7f8g, assembly 1, top view.
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