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SARS-COV-2 Spike RBDMACSp36 binding to hACE2

Electron Microscopy
3.12Å resolution
PDB entry 7fdi coloured by chain, front view.
PDB entry 7fdi coloured by chain, side view.
PDB entry 7fdi coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spike protein S2' and Processed angiotensin-converting enzyme 2
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Multimeric state: hetero dimer
Accessible surface area: 33752.96 Å2
Buried surface area: 2888.76 Å2
Dissociation area: 902.43 Å2
Dissociation energy (ΔGdiss): -3.79 kcal/mol
Dissociation entropy (TΔSdiss): 13.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-144194

Macromolecules

Processed angiotensin-converting enzyme 2
Chain: A
Length: 621 amino acids
Theoretical weight: 71.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 1-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Pfam: Angiotensin-converting enzyme
InterPro: Peptidase M2, peptidyl-dipeptidase A
Processed angiotensin-converting enzyme 2 in PDB entry 7fdi, assembly 1, front view.
Processed angiotensin-converting enzyme 2 in PDB entry 7fdi, assembly 1, side view.
Processed angiotensin-converting enzyme 2 in PDB entry 7fdi, assembly 1, top view.
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Spike protein S1
Chain: E
Length: 213 amino acids
Theoretical weight: 24.07 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-526; Coverage: 15%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
InterPro:
Spike protein S1 in PDB entry 7fdi, assembly 1, front view.
Spike protein S1 in PDB entry 7fdi, assembly 1, side view.
Spike protein S1 in PDB entry 7fdi, assembly 1, top view.
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