› 7fge

X-ray diffraction
2.8Å resolution

A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus

Released:
DOI: 10.2210/pdb7fge/pdb
PDB entry 7fge coloured by chain, front view.
PDB entry 7fge coloured by chain, side view.
PDB entry 7fge coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel.
Li L, Chai Y, Peng W, Li D, Sun L, Gao GF, Qi J, Xiao H, Liu WJ, von Itzstein M, Gao F
OpenAccess logo Proc Natl Acad Sci U S A 119 e2210724119 (2022)
PMID: 36191180

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
toad NA (PER) Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 489 amino acids
Theoretical weight: 53.58 KDa
Source organism: unidentified influenza virus
Expression system: Baculovirus expression vector pFastBac1-HM

Ligands and Environments

2 bound ligands:
Ligand BCZ 8 x BCZ
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 105.215Å b: 135.124Å c: 135.449Å
α: 90° β: 103.85° γ: 90°
R-values:
R R work R free
0.232 0.23 0.291
Expression system: Baculovirus expression vector pFastBac1-HM

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