› 7fqh

X-ray diffraction
2.18Å resolution

Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-1-[1-[4-(cyclopropylmethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Released:
DOI: 10.2210/pdb7fqh/pdb
PDB entry 7fqh coloured by chain, front view.
PDB entry 7fqh coloured by chain, side view.
PDB entry 7fqh coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ehler A, Benz J, Bartels B, Hewings-David S, Rudolph MG

Function and Biology Details

Reaction catalysed: 
Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Legumain Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 444 amino acids
Theoretical weight: 50.88 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q99538 (Residues: 18-433; Coverage: 100%)
Gene names: LGMN, PRSC1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand WR9 3 x WR9
Ligand EDO 2 x EDO
Ligand NAG 2 x NAG
1 modified residue:
Ligand SNN 3 x SNN

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P321
Unit cell:
a: 117.798Å b: 117.798Å c: 102.812Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.223 0.272
Expression system: Drosophila

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