EC 3.4.22.34: Legumain
Reaction catalysed:
Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.
Systematic name:
-
Alternative Name(s):
- Asparaginyl endopeptidase
- Bean endopeptidase
- Citvac
- Hemoglobinase
- PRSC1 gene product (Homo sapiens)
- Phaseolin
- Proteinase B
- Vicilin peptidohydrolase
GO terms
Biochemical function:
Biological process:
- positive regulation of endothelial cell chemotaxis
- cellular response to amyloid-beta
- negative regulation of ERBB signaling pathway
- positive regulation of long-term synaptic potentiation
- self proteolysis
- activation of cysteine-type endopeptidase activity
- dendritic spine organization
- positive regulation of monocyte chemotaxis
- cellular response to calcium ion
- protein maturation
- proteolysis involved in protein catabolic process
- positive regulation of mitotic cell cycle
- negative regulation of neuron apoptotic process
- vitamin D metabolic process
- negative regulation of multicellular organism growth
- cellular response to hepatocyte growth factor stimulus
- receptor catabolic process
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- negative regulation of gene expression
- response to acidic pH
- associative learning
- positive regulation of cell population proliferation
- memory
- vacuolar protein processing
- proteolysis
- renal system process
Protein families (Pfam)
