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Structure of liver pyruvate kinase in complex with allosteric modulator 44

X-ray diffraction
1.769Å resolution
PDB entry 7fsd coloured by chain, front view.
PDB entry 7fsd coloured by chain, side view.
PDB entry 7fsd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pyruvate kinase PKLR
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Multimeric state: homo tetramer
Accessible surface area: 56793.63 Å2
Buried surface area: 22584.92 Å2
Dissociation area: 3,184.39 Å2
Dissociation energy (ΔGdiss): 30.83 kcal/mol
Dissociation entropy (TΔSdiss): 15.94 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-542216
Assembly 2
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Assembly Name: Pyruvate kinase PKLR
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Multimeric state: homo tetramer
Accessible surface area: 55902.27 Å2
Buried surface area: 22448.15 Å2
Dissociation area: 3,166.65 Å2
Dissociation energy (ΔGdiss): 30.85 kcal/mol
Dissociation entropy (TΔSdiss): 15.92 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-542216

Macromolecules

Pyruvate kinase PKLR
Chains: A, B, C, D, E, F, G, H
Length: 447 amino acids
Theoretical weight: 48.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30613 (Residues: 34-160, 262-574; Coverage: 77%)
  • Best match: P30613-2 (Residues: 3-129, 231-543)
Gene names: PK1, PKL, PKLR
Pfam:
InterPro:
Pyruvate kinase PKLR in PDB entry 7fsd, assembly 1, front view.
Pyruvate kinase PKLR in PDB entry 7fsd, assembly 1, side view.
Pyruvate kinase PKLR in PDB entry 7fsd, assembly 1, top view.
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