› › Structure analysis

Crystal Structure of human FABP4 in complex with rac-(1R,2S)-2-[(3,4-dichlorophenoxy)methyl]cyclohexane-1-carboxylic acid, i.e. SMILES C1CC[C@H]([C@H](C1)C(=O)O)COc1cc(c(cc1)Cl)Cl with IC50=3.73482 microM

X-ray diffraction
1.02Å resolution
PDB entry 7fx4 coloured by chain, front view.
PDB entry 7fx4 coloured by chain, side view.
PDB entry 7fx4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fatty acid-binding protein, adipocyte
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Multimeric state: monomeric
Accessible surface area: 7142.43 Å2
Buried surface area: 652.81 Å2
Dissociation area: 81.64 Å2
Dissociation energy (ΔGdiss): 0.23 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147213

Macromolecules

Fatty acid-binding protein, adipocyte
Chain: A
Length: 135 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15090 (Residues: 1-132; Coverage: 100%)
Gene name: FABP4
Pfam: Lipocalin / cytosolic fatty-acid binding protein family
Fatty acid-binding protein, adipocyte in PDB entry 7fx4, assembly 1, front view.
Fatty acid-binding protein, adipocyte in PDB entry 7fx4, assembly 1, side view.
Fatty acid-binding protein, adipocyte in PDB entry 7fx4, assembly 1, top view.
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