PDB 7g2r biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Autotaxin
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Multimeric state: monomeric

Accessible surface area: 34423.46 Å²

Buried surface area: 3159.34 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-179148

$Monomeric assembly 1 of PDB entry 7g2r coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Autotaxin;</li> <li class='image_legend_li'>1 copy of alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of CALCIUM ION;</li> <li class='image_legend_li'>1 copy of (4R)-7-[5-{2-cyclopropyl-6-[(oxan-4-yl)methoxy]pyridine-4-carbonyl}-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-2(1H)-carbonyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of POTASSIUM ION;</li> <li class='image_legend_li'>1 copy of ZINC ION;</li> <li class='image_legend_li'>1 copy of SODIUM ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7g2r coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Autotaxin;</li> <li class='image_legend_li'>1 copy of alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of CALCIUM ION;</li> <li class='image_legend_li'>1 copy of (4R)-7-[5-{2-cyclopropyl-6-[(oxan-4-yl)methoxy]pyridine-4-carbonyl}-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-2(1H)-carbonyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of POTASSIUM ION;</li> <li class='image_legend_li'>1 copy of ZINC ION;</li> <li class='image_legend_li'>1 copy of SODIUM ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7g2r coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Autotaxin;</li> <li class='image_legend_li'>1 copy of alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose;</li> <li class='image_legend_li'>1 copy of CALCIUM ION;</li> <li class='image_legend_li'>1 copy of (4R)-7-[5-{2-cyclopropyl-6-[(oxan-4-yl)methoxy]pyridine-4-carbonyl}-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-2(1H)-carbonyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of POTASSIUM ION;</li> <li class='image_legend_li'>1 copy of ZINC ION;</li> <li class='image_legend_li'>1 copy of SODIUM ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Autotaxin

Chain: A
Length: 846 amino acids
Theoretical weight: 97.34 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:

Canonical: Q64610 (Residues: 28-887; Coverage: 97%)
Best match: Q64610-2 (Residues: 28-862)

Gene names: Atx, Enpp2, Npps2
Pfam:

Somatomedin B domain
Type I phosphodiesterase / nucleotide pyrophosphatase
DNA/RNA non-specific endonuclease

Autotaxin in PDB entry 7g2r, assembly 1, front view.

Autotaxin in PDB entry 7g2r, assembly 1, side view.

Autotaxin in PDB entry 7g2r, assembly 1, top view.

FASTA Sequence


    >pdb|7g2r|A

FTASRIKRAEWDEGPPTVLSDSPWTATSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEIGGRHHHHHHHH

PDBe-KB: UniProt Coverage View: Q64610

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UniProt

Q64610

Mapping to UniProt ENPP2_RAT

Chains

RSRZ Outlier Chain A

Chain A

Flexibility predictions

Consensus disorder prediction

Ligand binding sites

Residues binding (4R)-7-[5-{2-cyclopropyl-6-[(oxan-4-yl)methoxy]pyridine-4-carbonyl}-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrole-2(1H)-carbonyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3(2H)-one <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/XSU_200.svg" />

Residues binding CALCIUM ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/CA_200.svg" />

Residues binding 2-acetamido-2-deoxy-beta-D-glucopyranose <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NAG_200.svg" />

Residues binding alpha-D-mannopyranose <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/MAN_200.svg" />

Residues binding CHLORIDE ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/CL_200.svg" />

Residues binding ZINC ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ZN_200.svg" />

Residues binding ACETATE ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/ACT_200.svg" />

Residues binding POTASSIUM ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/K_200.svg" />

Residues binding SODIUM ION <img src="https://www.ebi.ac.uk/pdbe/static/files/pdbechem_v2/NA_200.svg" />

Sequence conservation

Amino acid probabilities The amino acid probabilities are calculated using HMM profiles based on multiple sequence alignments. Click to see more details...

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FASTA (Protein chains A)
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PDBe › 7g2r › Structure analysis

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7g2r › Structure analysis