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PanDDA analysis group deposition -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with Z1216833237

X-ray diffraction
1.799Å resolution
PDB entry 7h28 coloured by chain, front view.
PDB entry 7h28 coloured by chain, side view.
PDB entry 7h28 coloured by chain, top view.
Source organism: Zika virus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine protease NS3
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Multimeric state: hetero dimer
Accessible surface area: 9754.76 Å2
Buried surface area: 4457.08 Å2
Dissociation area: 2,073.08 Å2
Dissociation energy (ΔGdiss): 24.82 kcal/mol
Dissociation entropy (TΔSdiss): 11.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174292

Macromolecules

Serine protease subunit NS2B
Chain: A
Length: 46 amino acids
Theoretical weight: 5.07 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q32ZE1 (Residues: 1414-1457; Coverage: 1%)
Pfam: Flavivirus non-structural protein NS2B
Serine protease subunit NS2B in PDB entry 7h28, assembly 1, front view.
Serine protease subunit NS2B in PDB entry 7h28, assembly 1, side view.
Serine protease subunit NS2B in PDB entry 7h28, assembly 1, top view.
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Serine protease NS3
Chain: B
Length: 168 amino acids
Theoretical weight: 18.12 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q32ZE1 (Residues: 1509-1675; Coverage: 5%)
Pfam: Peptidase S7, Flavivirus NS3 serine protease
Serine protease NS3 in PDB entry 7h28, assembly 1, front view.
Serine protease NS3 in PDB entry 7h28, assembly 1, side view.
Serine protease NS3 in PDB entry 7h28, assembly 1, top view.
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