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Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z315923746 (A71EV2A-x1109)

X-ray diffraction
1.86Å resolution
PDB entry 7h4u coloured by chain, front view.
PDB entry 7h4u coloured by chain, side view.
PDB entry 7h4u coloured by chain, top view.
Source organism: Coxsackievirus A16
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease 2A
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Multimeric state: monomeric
Accessible surface area: 7067.65 Å2
Buried surface area: 105.55 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-241973

Macromolecules

Protease 2A
Chain: A
Length: 150 amino acids
Theoretical weight: 16.49 KDa
Source organism: Coxsackievirus A16
Expression system: Escherichia coli
UniProt:
  • Canonical: Q65900 (Residues: 869-1012; Coverage: 7%)
Pfam: Picornavirus core protein 2A
Protease 2A in PDB entry 7h4u, assembly 1, front view.
Protease 2A in PDB entry 7h4u, assembly 1, side view.
Protease 2A in PDB entry 7h4u, assembly 1, top view.
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