› 7hmq

X-ray diffraction
1.43Å resolution

PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1267773633

Released:
DOI: 10.2210/pdb7hmq/pdb
PDB entry 7hmq coloured by chain, front view.
PDB entry 7hmq coloured by chain, side view.
PDB entry 7hmq coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Kim Y, Marples P, Fearon D, von Delft F, Knapp S, Kraemer A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-563116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase TRIM21 Chain: B
Molecule details ›
Chain: B
Length: 188 amino acids
Theoretical weight: 21.6 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62191 (Residues: 291-470; Coverage: null%)
Gene names: Ro52, Ssa1, Trim21
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand A1A36 1 x A1A36
Ligand EDO 1 x EDO
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: I4
Unit cell:
a: 95.48Å b: 95.48Å c: 45.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.179 0.203
Expression system: Escherichia coli

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