› › Structure analysis

Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Selumetinib

X-ray diffraction
3.21Å resolution
PDB entry 7juz coloured by chain, front view.
PDB entry 7juz coloured by chain, side view.
PDB entry 7juz coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Kinase suppressor of Ras 1 and Dual specificity mitogen-activated protein kinase kinase 1
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 27166.6 Å2
Buried surface area: 3574.15 Å2
Dissociation area: 941.94 Å2
Dissociation energy (ΔGdiss): 3.11 kcal/mol
Dissociation entropy (TΔSdiss): 13.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151560

Macromolecules

Kinase suppressor of Ras 1
Chain: A
Length: 334 amino acids
Theoretical weight: 38.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IVT5 (Residues: 591-899; Coverage: 34%)
Gene names: KSR, KSR1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
Kinase suppressor of Ras 1 in PDB entry 7juz, assembly 1, front view.
Kinase suppressor of Ras 1 in PDB entry 7juz, assembly 1, side view.
Kinase suppressor of Ras 1 in PDB entry 7juz, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8IVT5  
133450100150200250300
 
100200300MSYYHHHHHHDYDIPTTENLYFQGAPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEI
UniProt
Q8IVT5
Chains
Domains
Secondary structure
Flexibility predictions
Topology annotations
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Dual specificity mitogen-activated protein kinase kinase 1
Chain: C
Length: 384 amino acids
Theoretical weight: 43.12 KDa
Source organism: Oryctolagus cuniculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29678 (Residues: 35-393; Coverage: 91%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7juz, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7juz, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 7juz, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P29678  
138450100150200250300350
 
100200300MSYYHHHHHHDYDIPTTENLYFQGAKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
UniProt
P29678
Chains
Domains
Secondary structure
Flexibility predictions
Topology annotations
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

Search similar proteins

Quick links