7k0o

Electron Microscopy
3.1Å resolution

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-127404 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Serine palmitoyltransferase 1 Chains: A, E
Molecule details ›
Chains: A, E
Length: 473 amino acids
Theoretical weight: 52.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15269 (Residues: 1-473; Coverage: 100%)
Gene names: LCB1, SPTLC1
Sequence domains: Aminotransferase class I and II
Serine palmitoyltransferase 2 Chains: B, F
Molecule details ›
Chains: B, F
Length: 544 amino acids
Theoretical weight: 60.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15270 (Residues: 1-544; Coverage: 97%)
Gene names: KIAA0526, LCB2, SPTLC2
Sequence domains: Aminotransferase class I and II
Serine palmitoyltransferase small subunit A Chains: C, G
ORM1-like protein 3 Chains: D, H

Ligands and Environments


Cofactor: Ligand PLP 2 x PLP
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-22605
Expression system: Homo sapiens