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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: sphingolipid biosynthetic process
Cellular component: serine palmitoyltransferase complex

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EC 2.3.1.50: Serine C-palmitoyltransferase

Reaction catalysed:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)
Systematic name:
Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
Alternative Name(s):
  • 3-oxosphinganine synthetase
  • Acyl-CoA:serine C-2 acyltransferase decarboxylating
  • SPT
  • Serine palmitoyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00155
Domain description: Aminotransferase class I and II
Occurring in:
  1. Serine palmitoyltransferase 1
  2. Serine palmitoyltransferase 2
The deposited structure of PDB entry 7k0o contains 2 copies of Pfam domain PF00155 (Aminotransferase class I and II) in Serine palmitoyltransferase 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 7k0o contains 2 copies of Pfam domain PF00155 (Aminotransferase class I and II) in Serine palmitoyltransferase 2. Showing 1 copy in chain B.

PF04061
Domain description: ORMDL family
Occurring in:
  1. ORM1-like protein 3
The deposited structure of PDB entry 7k0o contains 2 copies of Pfam domain PF04061 (ORMDL family ) in ORM1-like protein 3. Showing 1 copy in chain D.

PF11779
Domain description: Small subunit of serine palmitoyltransferase-like
Occurring in:
  1. Serine palmitoyltransferase small subunit A
The deposited structure of PDB entry 7k0o contains 2 copies of Pfam domain PF11779 (Small subunit of serine palmitoyltransferase-like) in Serine palmitoyltransferase small subunit A. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR007203
Domain description: ORMDL family
Occurring in:
  1. ORM1-like protein 3
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Serine palmitoyltransferase 1
  2. Serine palmitoyltransferase 2
IPR004839
Domain description: Aminotransferase, class I/classII, large domain
Occurring in:
  1. Serine palmitoyltransferase 1
  2. Serine palmitoyltransferase 2
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Serine palmitoyltransferase 1
  2. Serine palmitoyltransferase 2
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Serine palmitoyltransferase 1
  2. Serine palmitoyltransferase 2
IPR024512
Domain description: Small subunit of serine palmitoyltransferase-like
Occurring in:
  1. Serine palmitoyltransferase small subunit A
IPR001917
Domain description: Aminotransferase, class-II, pyridoxal-phosphate binding site
Occurring in:
  1. Serine palmitoyltransferase 2

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