› 7k18

Electron Microscopy
3.3Å resolution

Cardiac Sodium channel with toxin bound

Released:
DOI: 10.2210/pdb7k18/pdb
PDB entry 7k18 coloured by chain, front view.
PDB entry 7k18 coloured by chain, side view.
PDB entry 7k18 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomès R, Zheng N, Catterall WA
OpenAccess logo Nat Commun 12 128 (2021)
PMID: 33397917
Related structures: EMD-22621

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147339 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Green fluorescent protein; Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1838 amino acids
Theoretical weight: 209.04 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P15389 (Residues: 1-1898; Coverage: 78%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, Scn5a
Sequence domains:
Alpha-like toxin Lqh3 Chain: B
Molecule details ›
Chain: B
Length: 67 amino acids
Theoretical weight: 7.07 KDa
UniProt:
  • Canonical: P56678 (Residues: 1-67; Coverage: 100%)
Sequence domains: Scorpion toxin-like domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand 6OU 11 x 6OU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-22621
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology.
Catterall WA. (2023)
3 more

9 mentions without citation

A structural atlas of druggable sites on Nav channels.
Li et al. (2024)
8 more