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Cardiac Sodium channel with toxin bound

Electron Microscopy
3.3Å resolution
PDB entry 7k18 coloured by chain, front view.
PDB entry 7k18 coloured by chain, side view.
PDB entry 7k18 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-like toxin Lqh3 and Green fluorescent protein, Sodium channel protein type 5 subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 62718.69 Å2
Buried surface area: 2810.27 Å2
Dissociation area: 440.67 Å2
Dissociation energy (ΔGdiss): -3.84 kcal/mol
Dissociation entropy (TΔSdiss): 11.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147339

Macromolecules

Green fluorescent protein; Sodium channel protein type 5 subunit alpha
Chain: A
Length: 1838 amino acids
Theoretical weight: 209.04 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P15389 (Residues: 1-1898; Coverage: 78%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
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Gene names: GFP, Scn5a
Pfam:
InterPro:
Green fluorescent protein in PDB entry 7k18, assembly 1, front view.
Green fluorescent protein in PDB entry 7k18, assembly 1, side view.
Green fluorescent protein in PDB entry 7k18, assembly 1, top view.
Molecule details ›

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Alpha-like toxin Lqh3
Chain: B
Length: 67 amino acids
Theoretical weight: 7.07 KDa
UniProt:
  • Canonical: P56678 (Residues: 1-67; Coverage: 100%)
Pfam: Scorpion toxin-like domain
InterPro:
Alpha-like toxin Lqh3 in PDB entry 7k18, assembly 1, front view.
Alpha-like toxin Lqh3 in PDB entry 7k18, assembly 1, side view.
Alpha-like toxin Lqh3 in PDB entry 7k18, assembly 1, top view.
Molecule details ›

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