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Herceptin Diabody with R83T, E85C Mutations

X-ray diffraction
2.3Å resolution
PDB entry 7kbp coloured by chain, front view.
PDB entry 7kbp coloured by chain, side view.
PDB entry 7kbp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: IG-heavy chain
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Multimeric state: homo dimer
Accessible surface area: 20468.69 Å2
Buried surface area: 5996.08 Å2
Dissociation area: 2,009.46 Å2
Dissociation energy (ΔGdiss): 24.56 kcal/mol
Dissociation entropy (TΔSdiss): 13.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-214362
Assembly 2 (preferred)
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Assembly Name: IG-heavy chain
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Multimeric state: homo dimer
Accessible surface area: 19716.87 Å2
Buried surface area: 5468.27 Å2
Dissociation area: 2,044.6 Å2
Dissociation energy (ΔGdiss): 24.04 kcal/mol
Dissociation entropy (TΔSdiss): 13.84 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-214362

Macromolecules

Single-chain Fv
Chains: A, B, C, D
Length: 241 amino acids
Theoretical weight: 26.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
Single-chain Fv in PDB entry 7kbp, assembly 2, front view.
Single-chain Fv in PDB entry 7kbp, assembly 2, side view.
Single-chain Fv in PDB entry 7kbp, assembly 2, top view.
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