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Murine core lysosomal multienzyme complex (LMC) composed of acid beta-galactosidase (GLB1) and protective protein cathepsin A (PPCA, CTSA)

Electron Microscopy
4.59Å resolution
PDB entry 7kdv coloured by chain, front view.
PDB entry 7kdv coloured by chain, side view.
PDB entry 7kdv coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-galactosidase and Lysosomal protective protein
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Multimeric state: hetero dodecamer
Accessible surface area: 248351.08 Å2
Buried surface area: 39722.46 Å2
Dissociation area: 6,215.49 Å2
Dissociation energy (ΔGdiss): -44.56 kcal/mol
Dissociation entropy (TΔSdiss): 127.48 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-147792

Macromolecules

Beta-galactosidase
Chains: A, C, E, G, I, K
Length: 630 amino acids
Theoretical weight: 71.45 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23780 (Residues: 28-647; Coverage: 100%)
Gene names: Bgl, Glb-1, Glb1
Pfam:
InterPro:
Beta-galactosidase in PDB entry 7kdv, assembly 1, front view.
Beta-galactosidase in PDB entry 7kdv, assembly 1, side view.
Beta-galactosidase in PDB entry 7kdv, assembly 1, top view.
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Lysosomal protective protein
Chains: B, D, F, H, J, L
Length: 461 amino acids
Theoretical weight: 52.66 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P16675 (Residues: 24-474; Coverage: 100%)
Gene names: Ctsa, Ppgb
Pfam: Serine carboxypeptidase
InterPro:
Lysosomal protective protein in PDB entry 7kdv, assembly 1, front view.
Lysosomal protective protein in PDB entry 7kdv, assembly 1, side view.
Lysosomal protective protein in PDB entry 7kdv, assembly 1, top view.
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