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Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437

Electron Microscopy
3.8Å resolution
PDB entry 7kfh coloured by chain, front view.
PDB entry 7kfh coloured by chain, side view.
PDB entry 7kfh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GP2 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero dodecamer
Accessible surface area: 75361.17 Å2
Buried surface area: 41197.75 Å2
Dissociation area: 2,015.85 Å2
Dissociation energy (ΔGdiss): -3.6 kcal/mol
Dissociation entropy (TΔSdiss): 36.37 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-211934

Macromolecules

GP1
Chains: A, B, C
Length: 313 amino acids
Theoretical weight: 34.98 KDa
Source organism: Ebola virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 32-309; Coverage: 43%)
Gene name: GP
Pfam: Filovirus glycoprotein
InterPro: Filoviruses glycoprotein, extracellular domain
GP1 in PDB entry 7kfh, assembly 1, front view.
GP1 in PDB entry 7kfh, assembly 1, side view.
GP1 in PDB entry 7kfh, assembly 1, top view.
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Antibody Fab EBOV-437 light chain
Chains: J, K, L
Length: 215 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Antibody Fab EBOV-437 light chain in PDB entry 7kfh, assembly 1, front view.
Antibody Fab EBOV-437 light chain in PDB entry 7kfh, assembly 1, side view.
Antibody Fab EBOV-437 light chain in PDB entry 7kfh, assembly 1, top view.
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GP2
Chains: D, E, F
Length: 203 amino acids
Theoretical weight: 22.16 KDa
Source organism: Ebola virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05320 (Residues: 461-629; Coverage: 26%)
Gene name: GP
Pfam: Envelope glycoprotein GP2-like, HR1-HR2
GP2 in PDB entry 7kfh, assembly 1, front view.
GP2 in PDB entry 7kfh, assembly 1, side view.
GP2 in PDB entry 7kfh, assembly 1, top view.
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Antibody Fab EBOV-437 heavy chain
Chains: G, H, I
Length: 237 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
Antibody Fab EBOV-437 heavy chain in PDB entry 7kfh, assembly 1, front view.
Antibody Fab EBOV-437 heavy chain in PDB entry 7kfh, assembly 1, side view.
Antibody Fab EBOV-437 heavy chain in PDB entry 7kfh, assembly 1, top view.
Molecule details ›

Search similar proteins

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