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Cryo-EM Structure of Double ACE2-Bound SARS-CoV-2 Trimer Spike at pH 5.5

Electron Microscopy
3.74Å resolution
PDB entry 7knh coloured by chain, front view.
PDB entry 7knh coloured by chain, side view.
PDB entry 7knh coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 uncleaved Spike protein complex and Processed angiotensin-converting enzyme 2
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Multimeric state: hetero pentamer
Accessible surface area: 202551.71 Å2
Buried surface area: 43014.76 Å2
Dissociation area: 1,935.18 Å2
Dissociation energy (ΔGdiss): -10.67 kcal/mol
Dissociation entropy (TΔSdiss): 31.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-144663

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.4 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Pfam:
InterPro:
Spike glycoprotein in PDB entry 7knh, assembly 1, front view.
Spike glycoprotein in PDB entry 7knh, assembly 1, side view.
Spike glycoprotein in PDB entry 7knh, assembly 1, top view.
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Processed angiotensin-converting enzyme 2
Chains: D, E
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 19-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Pfam: Angiotensin-converting enzyme
InterPro: Peptidase M2, peptidyl-dipeptidase A
Processed angiotensin-converting enzyme 2 in PDB entry 7knh, assembly 1, front view.
Processed angiotensin-converting enzyme 2 in PDB entry 7knh, assembly 1, side view.
Processed angiotensin-converting enzyme 2 in PDB entry 7knh, assembly 1, top view.
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