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Human CYP3A4 bound to an inhibitor

X-ray diffraction
2.791Å resolution
PDB entry 7kvh coloured by chain, front view.
PDB entry 7kvh coloured by chain, side view.
PDB entry 7kvh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 3A4
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Multimeric state: homo dimer
Accessible surface area: 39304.19 Å2
Buried surface area: 3014.98 Å2
Dissociation area: 310.7 Å2
Dissociation energy (ΔGdiss): -13.88 kcal/mol
Dissociation entropy (TΔSdiss): 13.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140290

Macromolecules

Cytochrome P450 3A4
Chains: A, B
Length: 487 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08684 (Residues: 21-503; Coverage: 96%)
Gene names: CYP3A3, CYP3A4
Pfam: Cytochrome P450
InterPro:
Cytochrome P450 3A4 in PDB entry 7kvh, assembly 1, front view.
Cytochrome P450 3A4 in PDB entry 7kvh, assembly 1, side view.
Cytochrome P450 3A4 in PDB entry 7kvh, assembly 1, top view.
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