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HPK1 IN COMPLEX WITH COMPOUND 18

X-ray diffraction
1.85Å resolution
PDB entry 7l25 coloured by chain, front view.
PDB entry 7l25 coloured by chain, side view.
PDB entry 7l25 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase kinase kinase kinase 1
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Multimeric state: monomeric
Accessible surface area: 14244.09 Å2
Buried surface area: 485.42 Å2
Dissociation area: 119.86 Å2
Dissociation energy (ΔGdiss): -2.26 kcal/mol
Dissociation entropy (TΔSdiss): -0.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187813
Assembly 2
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Assembly Name: Mitogen-activated protein kinase kinase kinase kinase 1
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Multimeric state: monomeric
Accessible surface area: 14053.46 Å2
Buried surface area: 491.7 Å2
Dissociation area: 125.61 Å2
Dissociation energy (ΔGdiss): -2.29 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-187813

Macromolecules

Mitogen-activated protein kinase kinase kinase kinase 1
Chains: A, B
Length: 289 amino acids
Theoretical weight: 32.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92918 (Residues: 6-294; Coverage: 35%)
Gene names: HPK1, MAP4K1
Pfam: Protein kinase domain
InterPro:
Mitogen-activated protein kinase kinase kinase kinase 1 in PDB entry 7l25, assembly 1, front view.
Mitogen-activated protein kinase kinase kinase kinase 1 in PDB entry 7l25, assembly 1, side view.
Mitogen-activated protein kinase kinase kinase kinase 1 in PDB entry 7l25, assembly 1, top view.
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