7l2x › Citations

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.

Zhang K, Julius D, Cheng Y
Cell 184 5138-5150.e12 (2021)
Related entries: 7l2h, 7l2i, 7l2j, 7l2k, 7l2l, 7l2m, 7l2n, 7l2o, 7l2p, 7l2r, 7l2s, 7l2t, 7l2u, 7l2v, 7l2w, 7mz5, 7mz6, 7mz7, 7mz9, 7mza, 7mzb, 7mzc, 7mzd, 7mze

Cited: 61 times
EuropePMC logo PMID: 34496225

Abstract

Many transient receptor potential (TRP) channels respond to diverse stimuli and conditionally conduct small and large cations. Such functional plasticity is presumably enabled by a uniquely dynamic ion selectivity filter that is regulated by physiological agents. What is currently missing is a "photo series" of intermediate structural states that directly address this hypothesis and reveal specific mechanisms behind such dynamic channel regulation. Here, we exploit cryoelectron microscopy (cryo-EM) to visualize conformational transitions of the capsaicin receptor, TRPV1, as a model to understand how dynamic transitions of the selectivity filter in response to algogenic agents, including protons, vanilloid agonists, and peptide toxins, permit permeation by small and large organic cations. These structures also reveal mechanisms governing ligand binding substates, as well as allosteric coupling between key sites that are proximal to the selectivity filter and cytoplasmic gate. These insights suggest a general framework for understanding how TRP channels function as polymodal signal integrators.

Reviews - 7l2x mentioned but not cited (1)

  1. Ligand-Binding Sites in Vanilloid-Subtype TRP Channels. Yelshanskaya MV, Sobolevsky AI. Front Pharmacol 13 900623 (2022)

Articles - 7l2x mentioned but not cited (2)



Reviews citing this publication (25)

  1. TRP channels: a journey towards a molecular understanding of pain. Rosenbaum T, Morales-Lázaro SL, Islas LD. Nat Rev Neurosci 23 596-610 (2022)
  2. Sensory TRP Channels in Three Dimensions. Diver MM, Lin King JV, Julius D, Cheng Y. Annu Rev Biochem 91 629-649 (2022)
  3. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Zhang M, Ma Y, Ye X, Zhang N, Pan L, Wang B. Signal Transduct Target Ther 8 261 (2023)
  4. Druggability of Voltage-Gated Sodium Channels-Exploring Old and New Drug Receptor Sites. Wisedchaisri G, Gamal El-Din TM. Front Pharmacol 13 858348 (2022)
  5. Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels. Cheng WWL, Arcario MJ, Petroff JT. Front Physiol 12 798102 (2021)
  6. Nobel somatosensations and pain. Reeh PW, Fischer MJM. Pflugers Arch 474 405-420 (2022)
  7. Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications. Yin Y, Wei L, Caseley EA, Lopez-Charcas O, Wei Y, Li D, Muench SP, Roger S, Wang L, Jiang LH. Med Res Rev 43 1346-1373 (2023)
  8. Ionic channels in nerve membranes, 50 years on. Hille B. Prog Biophys Mol Biol 169-170 12-20 (2022)
  9. New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility. Puthenveetil R, Christenson ET, Vinogradova O. Membranes (Basel) 12 227 (2022)
  10. Progress in the Structural Basis of thermoTRP Channel Polymodal Gating. Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A. Int J Mol Sci 24 743 (2023)
  11. "ThermoTRP" Channel Expression in Cancers: Implications for Diagnosis and Prognosis (Practical Approach by a Pathologist). Szallasi A. Int J Mol Sci 24 9098 (2023)
  12. Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells. Erin N, Szallasi A. Biomolecules 13 983 (2023)
  13. A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel. Amaya-Rodriguez CA, Carvajal-Zamorano K, Bustos D, Alegría-Arcos M, Castillo K. Front Pharmacol 14 1251061 (2023)
  14. Cryo-EM Analyses Permit Visualization of Structural Polymorphism of Biological Macromolecules. Chang WH, Huang SH, Lin HH, Chung SC, Tu IP. Front Bioinform 1 788308 (2021)
  15. The interaction of TRPV1 and lipids: Insights into lipid metabolism. Abdalla SS, Harb AA, Almasri IM, Bustanji YK. Front Physiol 13 1066023 (2022)
  16. Bridging structural and cell biology with cryo-electron microscopy. Nogales E, Mahamid J. Nature 628 47-56 (2024)
  17. Computational drug development for membrane protein targets. Li H, Sun X, Cui W, Xu M, Dong J, Ekundayo BE, Ni D, Rao Z, Guo L, Stahlberg H, Yuan S, Vogel H. Nat Biotechnol 42 229-242 (2024)
  18. Dilation of ion selectivity filters in cation channels. Huffer K, Tan XF, Fernández-Mariño AI, Dhingra S, Swartz KJ. Trends Biochem Sci 49 417-430 (2024)
  19. Inferiority complex: why do sensory ion channels multimerize? Gamper N, Shah S. Biochem Soc Trans 50 213-222 (2022)
  20. Mechanotransduction in the urothelium: ATP signalling and mechanoreceptors. Li X, Hu J, Yin P, Liu L, Chen Y. Heliyon 9 e19427 (2023)
  21. Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer. Ji R, Chang L, An C, Zhang J. Front Cell Dev Biol 12 1326231 (2024)
  22. Recent advances on the structure and the function relationships of the TRPV4 ion channel. Sánchez-Hernández R, Benítez-Angeles M, Hernández-Vega AM, Rosenbaum T. Channels (Austin) 18 2313323 (2024)
  23. Research focus and thematic trends of transient receptor potential vanilloid member 1 research: a bibliometric analysis of the global publications (1990-2023). Liu X, Zhang M, He C, Jia S, Xiang R, Xu Y, Zhao M. Naunyn Schmiedebergs Arch Pharmacol 397 1327-1346 (2024)
  24. Structural Plasticity of the Selectivity Filter in Cation Channels. Hendriks K, Öster C, Lange A. Front Physiol 12 792958 (2021)
  25. Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms. Huang J, Korsunsky A, Yazdani M, Chen J. Front Mol Neurosci 16 1334370 (2023)

Articles citing this publication (33)



Quick links