› 7lfb

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-518174 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab 7D6 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 24.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab 7D6 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Apolipoprotein L1 Chain: X
Molecule details ›
Chain: X
Length: 130 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
Expression system: Baculoviridae sp.
UniProt:
  • Canonical: O14791 (Residues: 61-172; Coverage: 30%)
Gene names: APOL, APOL1

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand MES 1 x MES
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 94.238Å b: 60.262Å c: 124.216Å
α: 90° β: 111.82° γ: 90°
R-values:
R R work R free
0.169 0.168 0.197
Expression systems:
  • Escherichia coli
  • Baculoviridae sp.

Quick links

Citations

2 review citations

Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective.
Sora et al. (2022)
1 more

1 mention without citation

Towards the accurate modelling of antibody-antigen complexes from sequence using machine learning and information-driven docking.
Giulini et al. (2024)