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Fab 7D6 bound to ApoL1 NTD

X-ray diffraction
1.913Å resolution
PDB entry 7lfb coloured by chain, front view.
PDB entry 7lfb coloured by chain, side view.
PDB entry 7lfb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Apolipoprotein L1 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 25164.09 Å2
Buried surface area: 7289.13 Å2
Dissociation area: 931.89 Å2
Dissociation energy (ΔGdiss): 2.43 kcal/mol
Dissociation entropy (TΔSdiss): 11.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208039

Macromolecules

Fab 7D6 heavy chain
Chain: H
Length: 225 amino acids
Theoretical weight: 24.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
Fab 7D6 heavy chain in PDB entry 7lfb, assembly 1, front view.
Fab 7D6 heavy chain in PDB entry 7lfb, assembly 1, side view.
Fab 7D6 heavy chain in PDB entry 7lfb, assembly 1, top view.
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Fab 7D6 light chain
Chain: L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
Fab 7D6 light chain in PDB entry 7lfb, assembly 1, front view.
Fab 7D6 light chain in PDB entry 7lfb, assembly 1, side view.
Fab 7D6 light chain in PDB entry 7lfb, assembly 1, top view.
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Apolipoprotein L1
Chain: X
Length: 130 amino acids
Theoretical weight: 15.29 KDa
Source organism: Homo sapiens
Expression system: Baculoviridae sp.
UniProt:
  • Canonical: O14791 (Residues: 61-172; Coverage: 30%)
Gene names: APOL, APOL1
InterPro: Apolipoprotein L
Apolipoprotein L1 in PDB entry 7lfb, assembly 1, front view.
Apolipoprotein L1 in PDB entry 7lfb, assembly 1, side view.
Apolipoprotein L1 in PDB entry 7lfb, assembly 1, top view.
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