› 7lkp

Electron Microscopy
3.27Å resolution

Structure of ATP-free human ABCA4

Released:
DOI: 10.2210/pdb7lkp/pdb
PDB entry 7lkp coloured by chain, front view.
PDB entry 7lkp coloured by chain, side view.
PDB entry 7lkp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structures of the eukaryotic retinal importer ABCA4.
Liu F, Lee J, Chen J
Elife 10 (2021)
PMID: 33605212
Related structures: EMD-23409

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Retinal-specific phospholipid-transporting ATPase ABCA4 Chain: A
Molecule details ›
Chain: A
Length: 2273 amino acids
Theoretical weight: 256.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78363 (Residues: 1-2273; Coverage: 100%)
Gene names: ABCA4, ABCR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
4 bound ligands:
Ligand NAG 6 x NAG
Ligand CLR 7 x CLR
Ligand POV 7 x POV
Ligand AJP 1 x AJP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-23409
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Phospholipid Scrambling by G Protein-Coupled Receptors.
Khelashvili et al. (2022)
6 more

10 mentions without citation

Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life.
Lewandowski et al. (2022)
9 more