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Structure of ATP-free human ABCA4

Source organism: Homo sapiens
Biochemical function: ABC-type transporter activity
Biological process: transmembrane transport
Cellular component: rod photoreceptor disc membrane

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EC 7.6.2.1: P-type phospholipid transporter

Reaction catalysed:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, phospholipid-flipping)
Alternative Name(s):
  • Aminophospholipid-transporting ATPase
  • Flippase
  • Phospholipid-transporting ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
The deposited structure of PDB entry 7lkp contains 2 copies of Pfam domain PF00005 (ABC transporter) in Retinal-specific phospholipid-transporting ATPase ABCA4. Showing 2 copies in chain A.

PF12698
Domain description: ABC-2 family transporter protein
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
The deposited structure of PDB entry 7lkp contains 2 copies of Pfam domain PF12698 (ABC-2 family transporter protein) in Retinal-specific phospholipid-transporting ATPase ABCA4. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR013525
Domain description: ABC-2 type transporter, transmembrane domain
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR026082
Domain description: ABC transporter A
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4
IPR005951
Domain description: Retinal-specific ATP-binding cassette transporter
Occurring in:
  1. Retinal-specific phospholipid-transporting ATPase ABCA4

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