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Human TRiC in ATP/AlFx closed state

Source organism: Homo sapiens
Biochemical function: ATP-dependent protein folding chaperone
Biological process: positive regulation of telomerase RNA localization to Cajal body
Cellular component: extracellular exosome

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00118
Domain description: TCP-1/cpn60 chaperonin family
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit epsilon. Showing 1 copy in chain A [auth L].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit beta. Showing 1 copy in chain C [auth M].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit delta. Showing 1 copy in chain E [auth N].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit gamma. Showing 1 copy in chain H [auth P].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit eta. Showing 1 copy in chain I [auth K].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit theta. Showing 1 copy in chain K [auth J].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit zeta. Showing 1 copy in chain N [auth A].
The deposited structure of PDB entry 7lum contains 2 copies of Pfam domain PF00118 (TCP-1/cpn60 chaperonin family) in T-complex protein 1 subunit alpha. Showing 1 copy in chain O.

InterPro InterPro annotations
IPR017998
Domain description: Chaperone tailless complex polypeptide 1 (TCP-1)
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR002194
Domain description: Chaperonin TCP-1, conserved site
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR027409
Domain description: GroEL-like apical domain superfamily
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR027410
Domain description: TCP-1-like chaperonin intermediate domain superfamily
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR027413
Domain description: GroEL-like equatorial domain superfamily
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR002423
Domain description: Chaperonin Cpn60/GroEL/TCP-1 family
Occurring in:
  1. T-complex protein 1 subunit zeta
  2. T-complex protein 1 subunit theta
  3. T-complex protein 1 subunit eta
  4. T-complex protein 1 subunit epsilon
  5. T-complex protein 1 subunit beta
  6. T-complex protein 1 subunit delta
  7. T-complex protein 1 subunit alpha
  8. T-complex protein 1 subunit gamma
IPR012719
Domain description: T-complex protein 1, gamma subunit
Occurring in:
  1. T-complex protein 1 subunit gamma
IPR012715
Domain description: T-complex protein 1, alpha subunit
Occurring in:
  1. T-complex protein 1 subunit alpha
IPR012717
Domain description: T-complex protein 1, delta subunit
Occurring in:
  1. T-complex protein 1 subunit delta
IPR012716
Domain description: T-complex protein 1, beta subunit
Occurring in:
  1. T-complex protein 1 subunit beta
IPR012718
Domain description: T-complex protein 1, epsilon subunit
Occurring in:
  1. T-complex protein 1 subunit epsilon
IPR012720
Domain description: T-complex protein 1, eta subunit
Occurring in:
  1. T-complex protein 1 subunit eta
IPR012721
Domain description: T-complex protein 1, theta subunit
Occurring in:
  1. T-complex protein 1 subunit theta
IPR012722
Domain description: T-complex protein 1, zeta subunit
Occurring in:
  1. T-complex protein 1 subunit zeta

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