Structure analysis

Crystal structure of the BCL6 BTB domain in complex with OICR-9320

X-ray diffraction
1.22Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 12454.68 Å2
Buried surface area: 4760.72 Å2
Dissociation area: 2,242.74 Å2
Dissociation energy (ΔGdiss): 24.62 kcal/mol
Dissociation entropy (TΔSdiss): 12.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-544655

Macromolecules

Chain: A
Length: 125 amino acids
Theoretical weight: 14.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Pfam: BTB/POZ domain
InterPro:

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