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Cryo-EM structure of ConSOSL.UFO.664 (ConS) in complex with bNAb PGT122

Electron Microscopy
3.12Å resolution
PDB entry 7lx2 coloured by chain, front view.
PDB entry 7lx2 coloured by chain, side view.
PDB entry 7lx2 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero nonamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero nonamer
Accessible surface area: 114896.55 Å2
Buried surface area: 52677.78 Å2
Dissociation area: 10,226.45 Å2
Dissociation energy (ΔGdiss): -153.04 kcal/mol
Dissociation entropy (TΔSdiss): 144.03 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-211802

Macromolecules

Env glycoprotein gp160
Chains: A, B, C
Length: 658 amino acids
Theoretical weight: 73.14 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
InterPro:
Env glycoprotein gp160 in PDB entry 7lx2, assembly 1, front view.
Env glycoprotein gp160 in PDB entry 7lx2, assembly 1, side view.
Env glycoprotein gp160 in PDB entry 7lx2, assembly 1, top view.
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PGT122 Fab light chain
Chains: L, M, O
Length: 213 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
InterPro:
PGT122 Fab light chain in PDB entry 7lx2, assembly 1, front view.
PGT122 Fab light chain in PDB entry 7lx2, assembly 1, side view.
PGT122 Fab light chain in PDB entry 7lx2, assembly 1, top view.
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PGT122 Fab heavy chain
Chains: H, N, P
Length: 235 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
InterPro:
PGT122 Fab heavy chain in PDB entry 7lx2, assembly 1, front view.
PGT122 Fab heavy chain in PDB entry 7lx2, assembly 1, side view.
PGT122 Fab heavy chain in PDB entry 7lx2, assembly 1, top view.
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