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Human DNA Pol eta S113A with rA-ended primer and dATP: in crystallo reaction for 300 s

X-ray diffraction
1.92Å resolution
PDB entry 7m8d coloured by chain, front view.
PDB entry 7m8d coloured by chain, side view.
PDB entry 7m8d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule
1 distinct DNA/RNA hybrid molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA polymerase eta and DNA
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Multimeric state: hetero trimer
Accessible surface area: 21727.31 Å2
Buried surface area: 6259.53 Å2
Dissociation area: 1,294.46 Å2
Dissociation energy (ΔGdiss): 35.37 kcal/mol
Dissociation entropy (TΔSdiss): 9.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113266

Macromolecules

DNA polymerase eta
Chain: A
Length: 435 amino acids
Theoretical weight: 48.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y253 (Residues: 1-432; Coverage: 61%)
Gene names: POLH, RAD30, RAD30A, XPV
Pfam:
InterPro:
DNA polymerase eta in PDB entry 7m8d, assembly 1, front view.
DNA polymerase eta in PDB entry 7m8d, assembly 1, side view.
DNA polymerase eta in PDB entry 7m8d, assembly 1, top view.
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DNA chain T
Name: DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.63 KDa
DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3') in PDB entry 7m8d, assembly 1, front view.
DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3') in PDB entry 7m8d, assembly 1, side view.
DNA (5'-D(*CP*AP*TP*TP*TP*TP*GP*AP*CP*GP*CP*T)-3') in PDB entry 7m8d, assembly 1, top view.
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DNA/RNA hybrid chain P
Name: DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*A)-D(P*A)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.76 KDa
DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*A)-D(P*A)-3') in PDB entry 7m8d, assembly 1, front view.
DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*A)-D(P*A)-3') in PDB entry 7m8d, assembly 1, side view.
DNA/RNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*A)-D(P*A)-3') in PDB entry 7m8d, assembly 1, top view.
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