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HIV-1 Protease (I84V) in Complex with PU2 (LR2-79)

X-ray diffraction
1.902Å resolution
PDB entry 7maf coloured by chain, front view.
PDB entry 7maf coloured by chain, side view.
PDB entry 7maf coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein p24
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Multimeric state: homo dimer
Accessible surface area: 9316.11 Å2
Buried surface area: 4198.93 Å2
Dissociation area: 2,032.63 Å2
Dissociation energy (ΔGdiss): 24.06 kcal/mol
Dissociation entropy (TΔSdiss): 11.56 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146209

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P12497 (Residues: 489-587; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
Protease in PDB entry 7maf, assembly 1, front view.
Protease in PDB entry 7maf, assembly 1, side view.
Protease in PDB entry 7maf, assembly 1, top view.
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