Structure analysis

LY-CoV1404 neutralizing antibody against SARS-CoV-2

X-ray diffraction
2.427Å resolution
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 27265.17 Å2
Buried surface area: 5310.75 Å2
Dissociation area: 852.66 Å2
Dissociation energy (ΔGdiss): -2.53 kcal/mol
Dissociation entropy (TΔSdiss): 12.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209839
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 27075.58 Å2
Buried surface area: 4873.41 Å2
Dissociation area: 773.18 Å2
Dissociation energy (ΔGdiss): -1.85 kcal/mol
Dissociation entropy (TΔSdiss): 12.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-209839

Macromolecules

Chains: A, D
Length: 223 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
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Chains: B, E
Length: 215 amino acids
Theoretical weight: 22.95 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
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Chains: C, F
Length: 205 amino acids
Theoretical weight: 23.17 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DTC2 (Residues: 329-527; Coverage: 16%)
Gene names: 2, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding
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