› 7mpe

Electron Microscopy
3.2Å resolution

Cryo-EM structure of the yeast cadmium factor 1 protein (Ycf1p)

Released:
DOI: 10.2210/pdb7mpe/pdb
PDB entry 7mpe coloured by chain, front view.
PDB entry 7mpe coloured by chain, side view.
PDB entry 7mpe coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters.
Bickers SC, Benlekbir S, Rubinstein JL, Kanelis V
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34021087
Related structures: EMD-23932

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + Cd(2+)(Side 1) = ADP + phosphate + Cd(2+)(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153834 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metal resistance protein YCF1 Chain: A
Molecule details ›
Chain: A
Length: 1537 amino acids
Theoretical weight: 174.02 KDa
Source organism: Saccharomyces cerevisiae
UniProt:
  • Canonical: P39109 (Residues: 1-1515; Coverage: 100%)
Gene names: YCF1, YD9302.11C, YDR135C
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-23932

Quick links

Citations

2 review citations

Mechanistic insights on KATP channel regulation from cryo-EM structures.
Driggers et al. (2023)
1 more

3 mentions without citation

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance.
Huang et al. (2023)
2 more