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Cryo-EM structure of the yeast cadmium factor 1 protein (Ycf1p)

Source organism: Saccharomyces cerevisiae
Biochemical function: ABC-type transporter activity
Biological process: cadmium ion transmembrane transport
Cellular component: membrane raft

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EC 7.6.2.3: ABC-type glutathione-S-conjugate transporter

Reaction catalysed:
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)
Alternative Name(s):
  • ABCC1 (gene name)
  • Glutathione-S-conjugate-translocating ATPase
  • MRP
  • MRP1
  • Multidrug resistance-associated protein 1
  • YBT1 (gene name)
  • YCF1 (gene name)

EC 7.2.2.2: ABC-type Cd(2+) transporter

Reaction catalysed:
ATP + H(2)O + Cd(2+)(Side 1) = ADP + phosphate + Cd(2+)(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, heavy-metal-exporting)
Alternative Name(s):
  • ABC-type cadmium-transporter
  • Cadmium-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Metal resistance protein YCF1
The deposited structure of PDB entry 7mpe contains 2 copies of Pfam domain PF00005 (ABC transporter) in Metal resistance protein YCF1. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. Metal resistance protein YCF1
The deposited structure of PDB entry 7mpe contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in Metal resistance protein YCF1. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Metal resistance protein YCF1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Metal resistance protein YCF1
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. Metal resistance protein YCF1
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. Metal resistance protein YCF1
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Metal resistance protein YCF1
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Metal resistance protein YCF1

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