Structure analysis

Native RhopH complex of the malaria parasite Plasmodium falciparum

Electron Microscopy
3.72Å resolution
Source organism: Plasmodium falciparum NF54
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 111447.03 Å2
Buried surface area: 18127.83 Å2
Dissociation area: 3,648.47 Å2
Dissociation energy (ΔGdiss): 20.48 kcal/mol
Dissociation entropy (TΔSdiss): 17.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-104246

Macromolecules

Chain: A
Length: 1417 amino acids
Theoretical weight: 167.44 KDa
Source organism: Plasmodium falciparum NF54
UniProt:
  • Canonical: A0A2I0BTS3 (Residues: 1-1417; Coverage: 100%)
Gene names: CK202_3849, CLAG3.1, CYL21_3022
Pfam: Cytoadherence-linked asexual protein
InterPro: Cytoadherence-linked asexual protein

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Chain: B
Length: 1378 amino acids
Theoretical weight: 162.89 KDa
Source organism: Plasmodium falciparum NF54
UniProt:
  • Canonical: A0A2I0BSI4 (Residues: 1-1378; Coverage: 100%)
Gene names: CK202_4006, CYL21_1043, RhopH2

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Chain: C
Length: 897 amino acids
Theoretical weight: 105 KDa
Source organism: Plasmodium falciparum NF54
UniProt:
  • Canonical: W7JUX6 (Residues: 1-897; Coverage: 100%)
Gene names: CK202_3967, CYL21_1038, PFNF54_02468, RhopH3
Pfam: RhopH3 C-terminal domain

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