Function and Biology

Structure of the E. coli PutA proline dehydrogenase domain (residues 86-630) complexed with cyclobutanecarboxylic acid

Source organism: Escherichia coli
Biochemical function: proline dehydrogenase activity
Biological process: proline catabolic process
Cellular component: not assigned

EC 1.5.5.2: Proline dehydrogenase

Reaction catalysed:
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
Systematic name:
L-proline:quinone oxidoreductase
Alternative Name(s):
  • L-proline dehydrogenase
  • L-proline:(acceptor) oxidoreductase

EC 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase

Reaction catalysed:
L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH
Systematic name:
L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • 1-pyrroline dehydrogenase
  • 1-pyrroline-5-carboxylate dehydrogenase
  • 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase
  • Delta(1)-pyrroline-5-carboxylate dehydrogenase
  • Delta(1)-pyrroline-5-carboxylic acid dehydrogenase
  • L-pyrroline-5-carboxylate-NAD(+) oxidoreductase
  • Pyrroline-5-carboxylate dehydrogenase
  • Pyrroline-5-carboxylic acid dehydrogenase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01619
Domain description: Proline dehydrogenase
Occurring in:
  1. Bifunctional protein PutA
The deposited structure of PDB entry 7mwu contains 1 copy of Pfam domain PF01619 (Proline dehydrogenase) in Bifunctional protein PutA. Showing 1 copy in chain A.

PF14850
Domain description: DNA-binding domain of Proline dehydrogenase
Occurring in:
  1. Bifunctional protein PutA
The deposited structure of PDB entry 7mwu contains 1 copy of Pfam domain PF14850 (DNA-binding domain of Proline dehydrogenase) in Bifunctional protein PutA. Showing 1 copy in chain A.

PF18327
Domain description: Proline utilization A proline dehydrogenase N-terminal domain
Occurring in:
  1. Bifunctional protein PutA
The deposited structure of PDB entry 7mwu contains 1 copy of Pfam domain PF18327 (Proline utilization A proline dehydrogenase N-terminal domain ) in Bifunctional protein PutA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015659
Domain description: Proline oxidase family
Occurring in:
  1. Bifunctional protein PutA
IPR002872
Domain description: Proline dehydrogenase domain
Occurring in:
  1. Bifunctional protein PutA
IPR029041
Domain description: FAD-linked oxidoreductase-like
Occurring in:
  1. Bifunctional protein PutA
IPR024082
Domain description: Proline dehydrogenase PutA, domain II
Occurring in:
  1. Bifunctional protein PutA
IPR041349
Domain description: Proline utilization A proline dehydrogenase N-terminal domain
Occurring in:
  1. Bifunctional protein PutA
IPR024089
Domain description: Proline dehydrogenase PutA, domain I/II
Occurring in:
  1. Bifunctional protein PutA
IPR024090
Domain description: Proline dehydrogenase PutA, domain I
Occurring in:
  1. Bifunctional protein PutA