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Crystal structure of HIV-1 Protease multiple mutants PRS17 bound to inhibitor Amprenavir

X-ray diffraction
1.47Å resolution
PDB entry 7n6x coloured by chain, front view.
PDB entry 7n6x coloured by chain, side view.
PDB entry 7n6x coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease
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Multimeric state: homo dimer
Accessible surface area: 9775.13 Å2
Buried surface area: 5002.32 Å2
Dissociation area: 2,182.74 Å2
Dissociation energy (ΔGdiss): 24.55 kcal/mol
Dissociation entropy (TΔSdiss): 11.48 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136860

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.79 KDa
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03367 (Residues: 501-599; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
Protease in PDB entry 7n6x, assembly 1, front view.
Protease in PDB entry 7n6x, assembly 1, side view.
Protease in PDB entry 7n6x, assembly 1, top view.
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