› 7neq

Electron Microscopy
3.12Å resolution

Structure of tariquidar-bound ABCG2

Released:
DOI: 10.2210/pdb7neq/pdb
PDB entry 7neq coloured by chain, front view.
PDB entry 7neq coloured by chain, side view.
PDB entry 7neq coloured by chain, top view.
Source organisms:
Primary publication:
Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
Kowal J, Ni D, Jackson SM, Manolaridis I, Stahlberg H, Locher KP
J Mol Biol 433 166980 (2021)
PMID: 33838147
Related structures: EMD-12290

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212846 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Broad substrate specificity ATP-binding cassette transporter ABCG2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 655 amino acids
Theoretical weight: 72.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNQ0 (Residues: 1-655; Coverage: 100%)
Gene names: ABCG2, ABCP, BCRP, BCRP1, MXR
Sequence domains:
5D3(Fab) light chain variable domain Chains: C, E
Molecule details ›
Chains: C, E
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Mus musculus
5D3(Fab) heavy chain variable domain Chains: D, F
Molecule details ›
Chains: D, F
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus
Expression system: Mus musculus

Ligands and Environments

4 bound ligands:
Ligand NAG 2 x NAG
Ligand U9N 1 x U9N
Ligand CLR 3 x CLR
Ligand R1H 1 x R1H
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-12290
Expression systems:
  • Homo sapiens
  • Mus musculus

Quick links

Citations

5 review citations

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.
Eckenstaler et al. (2021)
4 more

4 mentions without citation

A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance.
Huang et al. (2023)
3 more