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Structure of tariquidar-bound ABCG2

Electron Microscopy
3.12Å resolution
PDB entry 7neq coloured by chain, front view.
PDB entry 7neq coloured by chain, side view.
PDB entry 7neq coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Broad substrate specificity ATP-binding cassette transporter ABCG2 and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero hexamer
Accessible surface area: 64519.49 Å2
Buried surface area: 14194.1 Å2
Dissociation area: 2,351.68 Å2
Dissociation energy (ΔGdiss): 13.04 kcal/mol
Dissociation entropy (TΔSdiss): 24.56 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-212846

Macromolecules

Broad substrate specificity ATP-binding cassette transporter ABCG2
Chains: A, B
Length: 655 amino acids
Theoretical weight: 72.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNQ0 (Residues: 1-655; Coverage: 100%)
Gene names: ABCG2, ABCP, BCRP, BCRP1, MXR
Pfam:
InterPro:
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 7neq, assembly 1, front view.
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 7neq, assembly 1, side view.
Broad substrate specificity ATP-binding cassette transporter ABCG2 in PDB entry 7neq, assembly 1, top view.
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5D3(Fab) light chain variable domain
Chains: C, E
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
5D3(Fab) light chain variable domain in PDB entry 7neq, assembly 1, front view.
5D3(Fab) light chain variable domain in PDB entry 7neq, assembly 1, side view.
5D3(Fab) light chain variable domain in PDB entry 7neq, assembly 1, top view.
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5D3(Fab) heavy chain variable domain
Chains: D, F
Length: 221 amino acids
Theoretical weight: 23.84 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
5D3(Fab) heavy chain variable domain in PDB entry 7neq, assembly 1, front view.
5D3(Fab) heavy chain variable domain in PDB entry 7neq, assembly 1, side view.
5D3(Fab) heavy chain variable domain in PDB entry 7neq, assembly 1, top view.
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