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Akirin2 bound human proteasome

Electron Microscopy
3.2Å resolution
PDB entry 7nht coloured by chain, front view.
PDB entry 7nht coloured by chain, side view.
PDB entry 7nht coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexadecamer (preferred)
Entry contents: 15 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexadecamer
Accessible surface area: 119569.07 Å2
Buried surface area: 51334.68 Å2
Dissociation area: 1,565.4 Å2
Dissociation energy (ΔGdiss): 12.88 kcal/mol
Dissociation entropy (TΔSdiss): 11.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127160

Macromolecules

Proteasome subunit alpha type-2
Chain: A
Length: 234 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25787 (Residues: 1-234; Coverage: 100%)
Gene names: HC3, PSC3, PSMA2
Pfam:
InterPro:
Proteasome subunit alpha type-2 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-2 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-2 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-4
Chain: B
Length: 261 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25789 (Residues: 1-261; Coverage: 100%)
Gene names: HC9, PSC9, PSMA4
Pfam:
InterPro:
Proteasome subunit alpha type-4 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-4 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-4 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-7
Chain: C
Length: 248 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14818 (Residues: 1-248; Coverage: 100%)
Gene names: HSPC, PSMA7
Pfam:
InterPro:
Proteasome subunit alpha type-7 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-7 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-7 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-5
Chain: D
Length: 241 amino acids
Theoretical weight: 26.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28066 (Residues: 1-241; Coverage: 100%)
Gene name: PSMA5
Pfam:
InterPro:
Proteasome subunit alpha type-5 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-5 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-5 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-1
Chain: E
Length: 263 amino acids
Theoretical weight: 29.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25786 (Residues: 1-263; Coverage: 100%)
Gene names: HC2, NU, PROS30, PSC2, PSMA1
Pfam:
InterPro:
Proteasome subunit alpha type-1 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-1 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-1 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-3
Chain: F
Length: 255 amino acids
Theoretical weight: 28.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25788 (Residues: 1-255; Coverage: 100%)
Gene names: HC8, PSC8, PSMA3
Pfam:
InterPro:
Proteasome subunit alpha type-3 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-3 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-3 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit alpha type-6
Chain: G
Length: 246 amino acids
Theoretical weight: 27.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P60900 (Residues: 1-246; Coverage: 100%)
Gene names: PROS27, PSMA6
Pfam:
InterPro:
Proteasome subunit alpha type-6 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit alpha type-6 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit alpha type-6 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-7
Chain: H
Length: 277 amino acids
Theoretical weight: 30 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99436 (Residues: 1-277; Coverage: 100%)
Gene names: PSMB7, Z
Pfam:
InterPro:
Proteasome subunit beta type-7 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-7 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-7 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-3
Chain: I
Length: 205 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49720 (Residues: 1-205; Coverage: 100%)
Gene name: PSMB3
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-3 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-3 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-3 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-2
Chain: J
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49721 (Residues: 1-201; Coverage: 100%)
Gene name: PSMB2
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-2 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-2 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-2 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-5
Chain: K
Length: 263 amino acids
Theoretical weight: 28.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28074 (Residues: 1-263; Coverage: 100%)
Gene names: LMPX, MB1, PSMB5, X
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-5 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-5 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-5 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-1
Chain: L
Length: 241 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P20618 (Residues: 1-241; Coverage: 100%)
Gene names: PSC5, PSMB1
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-1 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-1 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-1 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-4
Chain: M
Length: 264 amino acids
Theoretical weight: 29.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28070 (Residues: 1-264; Coverage: 100%)
Gene names: PROS26, PSMB4
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-4 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-4 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-4 in PDB entry 7nht, assembly 1, top view.
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Proteasome subunit beta type-6
Chain: N
Length: 239 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P28072 (Residues: 1-239; Coverage: 100%)
Gene names: LMPY, PSMB6, Y
Pfam: Proteasome subunit
InterPro:
Proteasome subunit beta type-6 in PDB entry 7nht, assembly 1, front view.
Proteasome subunit beta type-6 in PDB entry 7nht, assembly 1, side view.
Proteasome subunit beta type-6 in PDB entry 7nht, assembly 1, top view.
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Akirin-2
Chains: c, d
Length: 203 amino acids
Theoretical weight: 22.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q53H80 (Residues: 1-203; Coverage: 100%)
Gene names: AKIRIN2, C6orf166
InterPro: Akirin
Akirin-2 in PDB entry 7nht, assembly 1, front view.
Akirin-2 in PDB entry 7nht, assembly 1, side view.
Akirin-2 in PDB entry 7nht, assembly 1, top view.
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