EC 3.6.4.13: RNA helicase
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
- CSFV NS3 helicase
- DBP2
- DDX17
- DDX25
- DDX3
- DDX3X
- DDX3Y
- DDX4
- DDX5
- DEAD-box RNA helicase
- DEAD-box protein DED1
- DEAH-box RNA helicase
- DEAH-box protein 2
- DED1
- DbpA
- Dex(H/D) RNA helicase
- EIF4A helicase
- EhDEAD1
- EhDEAD1 RNA helicase
- GRTH/DDX25
- KOKV helicase
- Mtr4p
- NPH-II
- Nonstructural protein 3 helicase
- RHA
- RNA helicase A
- RNA helicase DDX3
- RNA helicase Hera
- RNA-dependent ATPase
- TGBp1 NTPase/helicase domain
- VRH1
GO terms
Biochemical function:
- metal ion binding
- ribonucleoprotein complex binding
- identical protein binding
- pattern recognition receptor activity
- protein domain specific binding
- ATP hydrolysis activity
- hydrolase activity
- zinc ion binding
- ATP binding
- protein binding
- helicase activity
- single-stranded RNA binding
- double-stranded RNA binding
- RNA helicase activity
- RNA binding
- DNA binding
Biological process:
- antiviral innate immune response
- cellular response to virus
- cellular response to exogenous dsRNA
- positive regulation of response to cytokine stimulus
- type I interferon-mediated signaling pathway
- defense response to virus
- protein complex oligomerization
- innate immune response
- negative regulation of viral genome replication
- MDA-5 signaling pathway
- positive regulation of tumor necrosis factor production
- positive regulation of interleukin-6 production
- positive regulation of interferon-beta production
- positive regulation of interferon-alpha production
- protein sumoylation
- response to virus
- immune system process
Protein families (Pfam)![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF11648 (C-terminal domain of RIG-I) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF11648_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF11648 (C-terminal domain of RIG-I)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF00271_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF00271 (Helicase conserved C-terminal domain)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF18119 (RIG-I receptor C-terminal domain) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF18119_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF18119 (RIG-I receptor C-terminal domain)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF04851 (Type III restriction enzyme, res subunit) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF04851_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF04851 (Type III restriction enzyme, res subunit)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF00619 (Caspase recruitment domain) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF00619_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF00619 (Caspase recruitment domain)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span> (this domain is out of the observed residue ranges!).")
![The deposited structure of PDB entry 7niq contains 1 copy of Pfam domain PF16739 (Caspase recruitment domain) in Interferon-induced helicase C domain-containing protein 1. Showing 1 copy in chain A [auth B] (this domain is out of the observed residue ranges!).](https://www.ebi.ac.uk/pdbe/static/entry/7niq_1_B_Pfam_PF16739_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7niq</span> contains 1 copy of Pfam domain <span class='highlight'>PF16739 (Caspase recruitment domain)</span> in <span class='highlight'>Interferon-induced helicase C domain-containing protein 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span> (this domain is out of the observed residue ranges!).")
InterPro annotations