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CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class)

Electron Microscopy
4.3Å resolution
PDB entry 7niq coloured by chain, front view.
PDB entry 7niq coloured by chain, side view.
PDB entry 7niq coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon-induced helicase C domain-containing protein 1 and RNA
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Multimeric state: hetero trimer
Accessible surface area: 35967.97 Å2
Buried surface area: 6136.27 Å2
Dissociation area: 1,625.55 Å2
Dissociation energy (ΔGdiss): 36.9 kcal/mol
Dissociation entropy (TΔSdiss): 11.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185922

Macromolecules

Interferon-induced helicase C domain-containing protein 1
Chain: B
Length: 1025 amino acids
Theoretical weight: 116.12 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R5F7 (Residues: 1-1025; Coverage: 100%)
Gene name: Ifih1
Pfam:
InterPro:
Interferon-induced helicase C domain-containing protein 1 in PDB entry 7niq, assembly 1, front view.
Interferon-induced helicase C domain-containing protein 1 in PDB entry 7niq, assembly 1, side view.
Interferon-induced helicase C domain-containing protein 1 in PDB entry 7niq, assembly 1, top view.
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RNA chain C
Name: RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3')
Representative chains: C
Source organism: Pseudomonas virus phi6 [10879]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.55 KDa
RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3') in PDB entry 7niq, assembly 1, front view.
RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3') in PDB entry 7niq, assembly 1, side view.
RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3') in PDB entry 7niq, assembly 1, top view.
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RNA chain G
Name: RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3')
Representative chains: G
Source organism: Pseudomonas virus phi6 [10879]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.38 KDa
RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') in PDB entry 7niq, assembly 1, front view.
RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') in PDB entry 7niq, assembly 1, side view.
RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') in PDB entry 7niq, assembly 1, top view.
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